Background: Patients with autoimmune thyroid disease (AITD) have a higher prevalence of pernicious anemia compared with the general population. N Engl J Med 1975;292:282-4. Pernicious anemia, which causes low levels of red blood cells, results from an inability to absorb vitamin B-12. What do these figures mean – and are such levels a cause for concern? Watanabe H, Yoneda S, Motoyama Y, Mukai K, Okuno Y, Kozawa J, Nishizawa H, Maeda N, Otsuki M, Matsuoka TA, Morii E, Iwahashi H, Shimomura I. Intern Med. The test can be carried out comfortably and quickly at home; though must be ordered online and can be expensive.Â, Another method that requires a visit to the doctor for a blood test is the holo TC test, which only measures vitamin B12 that is bound to the transport molecules, transcobalamin. Only this bound form of B12 can be correctly transported to the tissue and body store and thus utilised by the body (7, 8). While free, unbound B12 can produce high levels in a serum test; it has no biological function whatsoever.Â, Multiple forms of the transcobalamin transport molecule exist – the one that is important here is transcobalamin II, as it allows B12 to become biologically available. Murphy, M. F., Sourial, N. A., Burman, J. F., Doyle, D. V., Tabaqchali, S. and Mollin, D. L. (1986), Megaloblastic anaemia due to vitamin B12 deficiency caused by small intestinal bacterial overgrowth: possible role of vitamin B12 analogues. Vitamin B12 and Vitamin D Levels in Patients with Autoimmune Hypothyroidism and Their Correlation with Anti-Thyroid Peroxidase Antibodies. oldest • newest. A doctor may use the results of a vitamin B-12 test to help form their diagnosis. MNT is the registered trade mark of Healthline Media. Read on to learn more about testing B-12 levels and what the test results mean. Clin Biochem 2003;36:585-90. Increased serum vitamin B12 levels are associated with adult-onset Still’s disease with reactive macrophage activation syndrome. If it’s due to nutritional deficiencies then you should eat more mineral rich food and/or create a supplement regiment. Just another idea for you to look at. They may experience movement problems in addition to delayed development. 1977;87:546-551. Vermorken. What do extremely high vitamin B12 blood values mean? NLM Finally, some cases show the over production of other molecules which also bond to vitamin B12, most commonly the so-called haptocorrin or R-binder, to which transcobalamin I and III belong. As a result, B12 bonds to these molecules instead of transcobalamin II; while serum values of B12 seem to rise, none of the B12 is available for the body to use.Â. MedlineWeb of Science. High serum folate levels can mask the symptoms of vitamin B-12 deficiency and make its neurological symptoms worse. Imbalance of bacteria can cause over absorption in the ileum. Yours may be none of those things but unless your gp has more info you can't just discount the more serious issues. Read more about... Vitamin B12; Vitamin and mineral deficiencies; Reply Like (0) Save post Report. The holo TC test only measures B12 that is attached to transcobalamin II, thus giving a much better indication of the available supply.Â. | The most comfortable way of doing this is by measuring the methylmalonic acid (MMA) in the urine, which determines how much vitamin B12 the cells actually receive. Also, liver disease, hereditary spherocytes and vitamin B12 deficiency are sometimes responsible for this type of result. Atrophic body gastritis in patients with autoimmune thyroid disease: an underdiagnosed association. I have just had a conversation with gp over the high b12 being... to get my cholesterol tested soon as it was very high last time it was tested a couple of years back. Blood 1984;63:779-83. Increased levels of vitamin B12 can exist for a number of reasons, which can be divided roughly into the following categories: This article will take a closer look at the causes of elevated B12 blood levels, as well as considering the necessary ways to respond. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. Patients with AITD have a high prevalence of B12 deficiency and particularly of pernicious anemia. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. My dog had a life-threatening form of auto-immune disease which caused anaemia & lead to bone marrow failure, so I have spent 4 years studying the disease & haematology - he has 3 monthly blood tests - he had a Giardia infection which caused his B12 level to go over 2,000 which was a huge shock but not dangerous!!! Gimsing P . PCA were also measured in 27 patients with B12 deficiency and were positive in 8 patients. Whilst low blood levels of vitamin B12 indicate deficiency in a test; elevated blood levels are also often discovered. If they have issues absorbing vitamin B-12 from food sources, oral supplements or injections of the vitamin can help to prevent symptoms and complications. Zittoun J, Farcet JP, Marquet J, Sultan C, Zittoun R. Cobalamin vitamin B12 (vitamin B12) and B12 binding proteins in hypereosinophilic syndromes and secondary eosinophilia. Gimsing P, Hippe E. Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast. British Journal of Haematology, 62: 7â12. These lab values help detect a vitamin B-12 deficiency during the early stages. ', Your doc is not correct. Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients. suggest you do a search on 'functional deficiency' on the PASoc forum. Centanni M, Marignani M, Gargano L, Corleto VD, Casini A, Delle Fave G, Andreoli M, Annibale B. Arch Intern Med. High B12 blood levels should always be examined further, in order to rule out any serious diseases. As it can be easier for their body to absorb supplements than naturally occurring vitamin B-12, older adults should aim to meet their vitamin B-12 needs through fortified foods and vitamin supplements. Vitamin B12 test: high blood levels.
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