", S. Bacci & S. Pandolfi & F. Pennoni, 2014.
", Silvia Bacci & Francesco Bartolucci & Giulia Bettin & Claudia Pigini, 2017. Recent reports i... Melanoma is the most aggressive skin cancer. Search for Silvia Pandolfi's work. All rights reserved. ", Bartolucci, Francesco & Giorgio E., Montanari & Pandolfi, Silvia, 2012.
We find that mel... Melanoma is one of the most aggressive types of human cancer, characterized by enhanced heterogeneity and resistance to conventional therapy at advanced stages. Search Search. ", Pieroni, Luca & d'Agostino, Giorgio & Bartolucci, Francesco, 2013. In particular, there is evidence that hypoxia promotes stem cell renewal in vitro as well as in vivo. & Hodge, Kari J.
There, details are also given on how to add or correct references and citations. The question of whether cancer stem/tumor-initiating cells (CSC/TIC) exist in human melanomas has arisen in the last few years.
Sorry, you need to be a researcher to join ResearchGate. All material on this site has been provided by the respective publishers and authors. We describe two complementary methods to enrich for melanoma CSC/TIC. "A joint model for longitudinal and survival data based on an AR(1) latent process," Working papers of the Department of Economics - University of Perugia (IT) 00014/2015, Università di Perugia, Dipartimento Economia. The... Activation of hypoxia-inducible factors (HIF), responsible for tumor angiogenesis and glycolytic switch, is regulated by reduced oxygen availability. ", Bartolucci, Francesco & Pennoni, Fulvia & Vittadini, Giorgio, 2015. To update listings or check citations waiting for approval, Silvia Pandolfi should log into the RePEc Author Service. Il sistema al momento non può eseguire l'operazione. Silvia Pandolfi. Here, we have used nonadherent spheres and the aldehyde dehydrogenase (ALDH) enzymatic activity to enrich for CSC/TIC in a collection of human mela-nomas obtained from a broad spectrum of sites and stages. ", Morgan, Grant B. I seguenti articoli sono uniti in Scholar. Considering that cancer cells are harboured in a hypoxic environment in vivo, we here tested the hypothesis that the p53 codon 72 proline allele confers a survival disadvantage in presence of hypoxia. The Hedgehog-GLI (HH-GLI) signaling plays a critical role in controlling growth and tissue patterning during embryogenesis and is implicated in a variety of human malignancies, including those of the skin. Here, we describe a protocol to me... HEDGEHOG (HH) signaling is a key regulator of tissue development and its aberrant activation is involved in several cancer types, including melanoma. ", Francesco Bartolucci & Fulvia Pennoni & Giorgio Vittadini, 2016. For general information on how to correct material on RePEc, see these instructions. ", F. Bartolucci & G. Montanari & S. Pandolfi, 2012. ".
To investigate p66(shc) involvement in human longevity, p66(shc) mRNA and protein were evaluated in fibroblasts from young people, elderly and centenarians, exposed to oxidative or hypoxic stress. Find your freedom in the music, find your Jesus, find your kubrik. ", Giorgio E. Montanari & Marco Doretti, 2019. ", Antonello Maruotti & Jan Bulla & Tanya Mark, 2019. Luciferase reporter assays are powerful tools to measure the specific ability of a transcription factor to bind to its consensus sequence and to activate transcription of target genes. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. ", Silvia BACCI & Francesco BARTOLUCCI & Silvia PANDOLFI, 2015. ", Pandolfi, Silvia & Bartolucci, Francesco & Friel, Nial, 2014.
Targeted therapies and immunotherapy have improved the survival of patients with metastatic melanoma in the last few years; however, available treatments are still unsatisfactory. Item selection by an extended Latent …
We h... p66(shc-/-) mice exhibit prolonged lifespan and increased resistance to oxidative and hypoxic stress. © 2008-2020 ResearchGate GmbH. The HEDGEHOG-GLI (HH-GLI) signalling is a key pathway critical in embryonic development, stem cell biology and tissue homeostasis. Here, we have used nonadherent spheres and the aldehyde dehydrogenase (ALDH) enzymatic activity to enrich for CSC/TIC in a collection of human melanomas obtained from a broad spectrum of sites and stages. Sign up to see all their posts in your feed. Dipartimento di Scienze Biomediche, Sperimentali e Cliniche "Mario Serio", PO-099 Targeting the mitogen activated protein kinase erk5 in human melanoma, ERK5 is activated by oncogenic BRAF and promotes melanoma growth, Abstract B39: Exome sequencing in primary melanoma identifies novel drivers of melanoma progression, Luciferase Reporter Assays to Study Transcriptional Activity of Hedgehog Signaling in Normal and Cancer Cells, HEDGEHOG/GLI-E2F1 axis modulates iASPP expression and function and regulates melanoma cell growth, Hedgehog-Gli signaling in basal cell carcinoma and other skin cancers: prospects for therapy, Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: Implications for cancer therapy, Regulation of melanoma initiating cells by Hedgehog signaling and SOX2, SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells, Culture and Isolation of Melanoma-Initiating Cells, WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function, HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells, The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming, The oncogenic WIP1 phosphatase controls HEDGEHOG_GLI1 signaling pathway, Melanoma Antigen-11 Inhibits the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 and Activates Hypoxic Response, The p53 codon 72 proline allele is endowed with enhanced cell-death inducing potential in cancer cells exposed to hypoxia, p66Shc/Notch-3 Interplay Controls Self-Renewal and Hypoxia Survival in Human Stem/Progenitor Cells of the Mammary Gland Expanded In Vitro as Mammospheres, p66(shc) is highly expressed in fibroblasts from centenarians, Dipartimento di Scienze Biomediche, Sperimentali e Cliniche, Dipartimento di Ematologia, Oncologia e Medicina di Laboratorio, Department of Medical and Surgical Sciences DIMEC, Department of Experimental, Diagnostic and Specialty Medicine DIMES, Center for Applied Biomedical Research (CRBA). ", Montanari, Giorgio E. & Doretti, Marco & Bartolucci, Francesco, 2017. ", Michael Brusco & Hans-Friedrich Köhn & Douglas Steinley, 2015. Therefore, there is urgent need to identify novel possible targets involved in melanoma growth. We and others have shown a reciprocal cross talk between HH signaling and p53, whose function is often impaired in melanoma. Skip slideshow. An Empirical Analysis, A dynamic inhomogeneous latent state model for measuring material deprivation, Journal of the Royal Statistical Society Series A, Time Use Habits of Italian Generation Y: Dimensions of Leisure Preferences, An Exact Method for Partitioning Dichotomous Items Within the Framework of the Monotone Homogeneity Model, Variable Weighting via Multidimensional IRT Models in Composite Indicators Construction, A classification of university courses based on students’ satisfaction: an application of a two-level mixture item response model, Quality & Quantity: International Journal of Methodology, [This author has chosen not to make the email address public], Bartolucci, Francesco & Marino, Maria Francesca & Pandolfi, Silvia, 2015. Silvia Pandolfi M Bonafé The preferential retention of the arginine allele at the p53 codon 72 locus is commonly observed in tumours from arginine/proline heterozygotes. Home Silvia Pandolfi. ", Bartolucci, Francesco & Montanari, Giorgio E. & Pandolfi, Silvia, 2015. Recently it has been demonstrated that the overexpression of well-defined transcription factors reprograms somatic cells to the pluripotent stem status. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. ", Francesco Bartolucci & Giorgio E. Montanari & Silvia Pandolfi, 2018. Le loro, Questo conteggio "Citato da" include citazioni ai seguenti articoli in Scholar. ", F. Bartolucci & A. Farcomeni & F. Pennoni, 2014. ERK5/BMK1 is a member of the... Malignant melanoma is among the most aggressive cancers and its incidence is increasing worldwide. & Baggett, Aaron R., 2016. The question of whether cancer stem/tumor-initiating cells (CSC/TIC) exist in human melanomas has arisen in the last few years. In recent years, aberrant activation of HH-GLI signalling has been linked to several types of cancer, including those of the skin, brain, lungs, prostate, gastrointestinal tract and blood. Research fellow of Statistics - Department of Economics, Finance & Statitics - University of Perugia - Longitudinal data - latent variable models - Mixture models - Markov chain Monte Carlo methods
Due to our privacy policy, only current members can send messages to people on ResearchGate. Silvia Pandolfi. ", Bartolucci, Francesco & Farcomeni, Alessio & Pennoni, Fulvia, 2012. It therefore seems reasonable that stem cell survival and hypoxia response are strictly connected at molecular level. Melanoma is the most aggressive skin cancer with a poor prognosis in advanced stages. We and others have previously shown that HEDGEHOG-GLI (HH-GLI) signaling is required for melanoma growth and for survival and expansion of melanoma-initiating cells (MICs). The preferential retention of the arginine allele at the p53 codon 72 locus is commonly observed in tumours from arginine/proline heterozygotes. This unit illustrates protocols for culture and isolation of human melanoma cancer stem cells/tumor-initiating cells (CSC/TIC). The comprehension of the basic biology of stem cells is expected to provide a useful insight into the pathogenesis of cancer. ", Giorgio E. Montanari & Silvia Pandolfi, 2018. ", Michela Gnaldi & Simone Del Sarto, 2018. ", Francesco Dotto & Alessio Farcomeni & Maria Grazia Pittau & Roberto Zelli, 2019.
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