Latitude and vitamin D production in the skin. To determine whether latitude influences vitamin D levels and to investigate the influence of other factors that may affect vitamin D levels, including sex, race, skin type, and body mass index. Produced by hydroxylation of vitamin D3 in the liver. Please note: If you have a promotional code you'll be prompted to enter it prior to confirming your order. Conclusion: “One pill every two weeks fights diabetes, cancers, heart failure, and 18 other diseases.”, Receptor gene can limit Vit D actually getting to cells, Health Problem about 10X more likely if low Vit D, Antibiotics health problems are eerily similar to those due to low Vit D, Why are doctors reluctant to accept Vit D, No – 10 minutes per day of sun-UVB is NOT enough, The Shadow Rule – you make Vitamin D when you are taller than your shadow – 1992. Our sample population was one of convenience and, as such, represents a much younger segment of the overall population. What's more, your skin's production of vitamin D is influenced by age (people ages 65 and over generate only one-fourth as much as people in their 20s do), skin color (African Americans have, on average, about half as much vitamin D in their blood as white Americans), and sunscreen use (though experts don't all agree on the extent to which sunscreen interferes with sun-related vitamin D production). Vitamin D would be essential if it did nothing else. From the Lake Erie College of Osteopathic Medicine in Erie, Pennsylvania (Dr Leary); the Russell Research Institute at Lutheran General Hospital in Downers Grove, Illinois (Ms Zamfirova and Mr Au); and the University of Minnesota in Minneapolis (Dr McCracken). Our data were likely skewed by the large proportion of the sample population being white, allowing few data points for Asian, Indian, and those categorized as “other.” Additionally, the limited number of data points available for participants with darker skin types limits the power of the study to make any conclusive findings with regards to those participants. How to Save 90%+ on Vitamins, Hormones:BUY Bulk Powder-Vit K2 Can Cost 30X More Than Gold! Physicians should be cognizant of these risk factors when deciding whom to screen. Vitamin D levels have been linked to bone health and to numerous diseases; however, an element that lacks substantial direct data and limits the evidence basis regarding whom to screen for vitamin D deficiency is the effect of latitude on vitamin D levels. But researchers have discovered that it's active in many tissues and cells besides bone and controls an enormous number of genes, including some associated with cancers, autoimmune disease, and infection. In fact, a large-scale randomized trial that would include 20,000 U.S. women and men has been proposed by Harvard researchers and will be considered for funding by the National Institutes of Health. Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D is a group of fat-soluble secosteroids responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, and multiple other biological effects. FREE e-BOOK! Inactivates the Vitamin D Nuclear Receptor. The influence of vitamin D deficiency on cancers and autoimmune diseases development. The sun's rays provide ultraviolet B (UVB) energy, and the skin uses it to start making vitamin D. (The skin actually produces a precursor that is converted into the active form of the vitamin by the liver and kidneys.) You will receive an email whenever this article is corrected, updated, or cited in the literature. Growing awareness of vitamin D's benefits coupled with the risk of vitamin D deficiency has led some experts to recommend a blood test that assesses the amount of vitamin D in the body. Vitamin D comes from the synthesis of UVB radiation, which is less than 5% of the sunshine. Exposure of the eyes to near-horizon sunshine may be a trigger for multiple sclerosis. All rights reserved. Latitude was found to be a statistically significant risk factor for vitamin D deficiency. Source: Office of Dietary Supplements, National Institutes of Health. By activating your account, you will create a login and password. Measurement of skeletal muscle motion in vivo with phase-contrast MR imaging. Powe C, Evans M, Wenger J, et al Vitamin D-binding protein and vitamin D status of black Americans and white Americans. Because vitamin D increases calcium absorption in the gastrointestinal tract, vitamin D toxicity results in marked hypercalcemia (total calcium greater than 11.1 mg/dL, beyond the normal range of 8.4 to 10.2 mg/dL), hypercalciuria, and high serum 25(OH)D levels (typically greater than 375 nmol/l [150 ng/mL]) . ARCHIVED CONTENT: As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Promising findings from observational studies don't always pan out when put to the test in clinical trials. © 2010 - 2020 Harvard University. Non-white race, male sex, and high body mass index were also statistically significant risk factors for vitamin D deficiency in regression models (. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. Many experts recommend a level of at least 32 and suggest that 800 to 1,000 IU of vitamin D per day is required to maintain that level. © 2020 by the American Osteopathic Association, This PDF is available to Subscribers Only. This site uses cookies. Physicians should be cognizant of these risk factors when deciding whom to screen. a Tables represent data for all people surveyed who gave complete answers to the participation questionnaire (including those who eventually met study exclusion criteria and were not part of the final data analysis). When controlled for other confounding variables, students at the Bradenton campus had statistically significant higher vitamin D levels. Step away from it and do something else. Holick M. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Multiple sclerosis in time and space--geographic clues to cause. The Cure For Yellow Toenail Fungus-High Dose Vitamin D3- Case Studies #17. Vitamin D … Although there's no agreement on an optimal level of 25(OH)D, deficiency is generally defined as a blood level less than 20 nanograms per milliliter, or 20 ng/mL (see chart). In June 2008, a study published in the Archives of Internal Medicine found that low blood levels of vitamin D were associated with a doubled risk of death overall and from cardiovascular causes in women and men (average age 62) referred to a cardiac center for coronary angiography. But don't just take two, because getting double doses of other vitamins and minerals can be unsafe (for example, too much vitamin A as retinol can cause hair loss and diarrhea and is associated with hip and other bone fractures, possibly due to an adverse interaction with vitamin D). Huotari A, Herzig K. Vitamin D and living in northern latitudes—an endemic risk area for vitamin D deficiency. J Am Osteopath Assoc 2017;117(7):433–439. Hagenau T, Vest R, Gissel T, et al Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis. It should be noted that mean levels in participants from both campuses were both in the nondeficient range. Although it did not achieve statistical significance, the breakdown by sex consistently showed higher average vitamin D levels in women at both campuses. Many calcium pills contain about 200 IU of vitamin D, so one multivitamin and two or three calcium pills should suffice. Logistic regression models revealed an adjusted OR of 3.3 (95% CI, 1.73-6.4) for deficient total vitamin D among Erie students. LIMITED TIME > 16 Fascinating Covid-19 & Spanish Flu Mysteries Solved! Please note the date each article was posted or last reviewed. We thank the following individuals for their contributions to making this study possible: Thurman Alvey, DO; Thomas Quinn, DO; Joseph Leary, DO; Louis C. Cavadini, DO; and Mark Kauffman, DO. The 1,100 IU dose — nearly three times the 400 IU per day recommended in federal and other expert guidelines — was correlated with a 35% higher blood level of vitamin D, on average. Once consent was received, participants were given surveys to elicit further demographic information before having blood collected. Incidence of childhood type 1 diabetes worldwide. Context: Vitamin D levels have been linked to bone health and to numerous diseases; however, an element that lacks substantial direct data and limits the evidence basis regarding whom to screen for vitamin D deficiency is the effect of latitude on vitamin D levels.. To determine whether latitude influences vitamin D levels and to investigate the influence of other factors that may affect vitamin D levels, including sex, race, skin type, and body mass index. Get health information and advice from the experts at Harvard Medical School. Abbreviations: BMI, body mass index; SPF, sun protection factor. Try a medium- to high-intensity workout like a brisk 30-minute walk, an aerobics class, or a game of tennis. However, some experts think testing is unnecessary as long as you get 800 to 1,000 IU of vitamin D a day. Vitamin D deficiency among professional basketball players. Participant demographics are presented in, Mean total vitamin D levels are reported in, Multivariate logistic regression results are presented in. The primary outcome of interest was the average levels of 25(OH)D in students between the campuses and their relationship to latitude. A total of 359 medical students (aged 22-57 years) were included in the study, 194 at the Bradenton campus and 214 at the Erie campus. Some people over age 60 have few, if any, symptoms of an underactive thyroid gland (hypothyroidism), while others experience the same symptoms younger people do. The vitamin D metabolite widely (and erroneously) considered best indicator of vitamin D "deficiency."
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