A study published in the "Journal of Clinical Investigation" in May 2010 found that folate could promote nerve repair in the central nervous system in rats. So far, the majority of research on vitamin D has looked at its role in the cause of the disease.”. 2020 May 27;11:454. doi: 10.3389/fneur.2020.00454. Does Vitamin D Affect Diabetic Neuropathic Pain and Balance. Front Neurol. “We’d now like to see more studies to understand whether taking vitamin D supplements could, in time, be an effective and safe treatment for people with MS,” Dr. Susan added. This work provides significant evidence that vitamin D is involved in the regeneration of myelin once the disease has started, Researchers, from the MS Society Cambridge Centre for Myelin Repair, identified that the ‘vitamin D receptor’ protein pairs with an existing protein, called the RXR gamma receptor, already known to be involved in the repair of myelin, the protective sheath surrounding nerve fibres. It is reported that more than 100,000 people in the U.K. have multiple sclerosis, and finding more treatments that can either stop, slow, or reverse the disease is a priority of the MS Society, said Dr. Susan Kohlhaas, Head of Biomedical Research at the U.K. MS Society. We also observed that vitamin D 2 supplementation induced an increase in axon diameter, suggesting that myelination was probably enhanced. Vitamin D is not the only beneficial vitamin for preventing permanent nerve damage. Vitamin D might also play a role in nerve regeneration after surgery. A study published in the "Journal of Neutotrauma" in October 2008 found that vitamin D-2, a type of vitamin D synthesized in plants, had a positive effect on nerve regeneration. 2014;208(1):69-75. doi: 10.1051/jbio/2014008. Copyright © 2020 Leaf Group Ltd., all rights reserved. Surgery can lead to tissue damage due to incisions, tissue movement or other manipulation that can occur during a procedure. Please check with the appropriate physician regarding health questions and concerns. Franklin said their current work provides vital evidence that Vitamin D is also involved in the regeneration of myelin once MS has started. This study on rats suggests that folate can aid in nerve regeneration and promote recovery from spinal cord injury. This work provides significant evidence that vitamin D is also involved in the regeneration of myelin once the disease has started. – Robin Franklin” In MS, the body’s own immune system attacks and damages myelin, causing disruption to messages sent around the brain and spinal cord; symptoms are unpredictable and include problems with mobility and balance, pain, and severe fatigue. Without this supplement, the nerve damage could become permanent. Previously, we demonstrated i) that ergocalciferol (vitamin D 2) increases axon diameter and potentiates nerve regeneration in a rat model of transected peripheral nerve and ii) that cholecalciferol (vitamin D3) improves breathing and hyper-reflexia in a rat model of paraplegia. We observed that vitamin D2 significantly (i) increased axogenesis and axon diameter; (ii) improved the responses of sensory neurons to metabolites such as KCl and lactic acid; and (iii) induced a fast-to-slow fiber type transition of the Tibialis anterior muscle. However, in some cases, your nerves can regenerate as part of the healing process -- and specific vitamins might play a role in this regeneration. 2009 Jan;26(1):97-108. doi: 10.1089/neu.2008.0695. Epub 2014 Jun 23. This work provides significant evidence that vitamin D is involved in the regeneration of myelin once the disease has started. We’d now like to see more studies to understand whether taking vitamin D supplements could, in time, be an effective and safe treatment for people with MS. Robin Franklin. While folate's effect on nerve repair in humans is not yet known, the vitamin might aid in nerve regeneration after surgery. In a previous study, using a rat model of nerve trauma, we demonstrated that vitamin D 2 is a potent compound that promoted axon sparing/regeneration and improved physiological maturation . Consuming folate can affect the activity of genes within your nerve cells, helping to regulate genes involved in healing. Although the effects of vitamin D-2 in regenerating human nerves is not well understood, the vitamin might aid in nerve regeneration after surgery. “This work provides significant evidence that vitamin D is involved in the regeneration of myelin once the disease has started. Please read our email privacy notice for details. COVID-19 is an emerging, rapidly evolving situation. At the end of this period, motor and sensitive responses of the regenerated axons were calculated and histological analysis was performed. A natural protein in our body plus Vitamin D, one of the easily sourced vitamins on the planet now, have the potential in repairing damage to the myelin sheath in people with multiple sclerosis (MS), according to a new study conducted by the University of Cambridge. What Are the Benefits of Taking Vitamin D3? Vitamin D can decrease pain in patients with diabetic neuropathy and promote nerve growth. Vitamin B-1, B-6 and B-12 are especially important for healthy nerves. We also observed that vitamin D 2 supplementation induced an increase in axon diameter, suggesting that myelination was probably enhanced . A protein activated by vitamin D could be involved in repairing damage to myelin in people with multiple sclerosis (MS), according to new research from the University of Cambridge. Why did FDA Approve a New Opioid Drug In spite of Warnings for Abuse? Vitamin D-2, the plant-based form of vitamin D, may be therapeutic for people suffering nerve damage. We are committed to protecting your personal information and being transparent about what information we hold. All Rights Reserved. Please enable it to take advantage of the complete set of features! In MS, the body’s own immune system attacks and damages myelin, causing disruption to messages sent around the brain and spinal cord; symptoms are unpredictable and include problems with mobility and balance, pain, and severe fatigue. 2020 Jan 16;13:171-179. doi: 10.2147/JPR.S203176. One vitamin that might help promote nerve healing after injury is vitamin B-9, or folate. So what do you think of this finding on Vitamin D and its treatment of nerve damage among MS sufferers? Clipboard, Search History, and several other advanced features are temporarily unavailable. Dr Susan Kohlhaas, Head of Biomedical Research at the MS Society, said: “More than 100,000 people in the UK have multiple sclerosis and finding treatments that can slow, stop or reverse the worsening of disability is a priority for the MS Society. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. HHS Vitamin D receptor–retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation. Source: Sahifa © Sahifa Copyright 2016 (28/07/17). doi: 10.1371/journal.pone.0065034. Vitamin D can decrease pain in patients with diabetic neuropathy and promote nerve growth. Our team periodically reviews articles in order to ensure content quality. The text in this work is licensed under a Creative Commons Attribution 4.0 International License. Patients suffering from this condition often have too little vitamin D. A research letter published in the "Archives of Internal Medicine" journal in April 2008 reported that all participants in a study conducted in Australia had insufficient levels of vitamin D. Participants experienced an initial decrease of 48.5 percent in pain scores and an additional 39.4 percent after three months. She continued: “For now though, this is early stage research that’s been done in the laboratory and more work is needed before we know whether it would hold true in people with MS. It’s not a good idea, however, to be deficient in vitamin D and we’d encourage anybody who thinks they might be to speak to their GP.” Vitamin D supplements protect you from developing peripheral neuropathy, according to the Bay Area Medical Information website. Website Design by: Datapartners Site Developed by: Noovo Creative, T-cell research paves way for potential new MS therapies, Intranasal drug slows MS progression in mice study, Siponimod approved for secondary progressive multiple sclerosis, FDA advises people with MS to avoid amalgam mercury tooth fillings. Vitamin D and Its Potential Interplay With Pain Signaling Pathways. Vitamin D could repair nerve damage in multiple sclerosis, study suggests A protein activated by vitamin D could be involved in repairing damage to myelin in people with multiple sclerosis (MS), according to new research from the University of Cambridge. Large tissue resections might cause permanent nerve damage, while small incisions may heal effectively. “This work provides significant evidence that vitamin D is involved in the regeneration of myelin once the disease has started,” Robin Franklin, a professor from the MS Society Cambridge Centre for Myelin Repair and the Wellcome Trust-Medical Research Council Stem Cell Institute, and who led the study, said. Vitamin E and niacin also play critical roles in nerve health. She was a personal trainer for four years with certifications from AFAA and NASM. I wish to receive a weekly Cambridge research news summary by email. In addition, functional recovery was not impaired by vitamin D supplementation. The study, published in the Journal of Cell Biology, offers significant evidence that vitamin D could be a possible treatment for MS in the future. doi: 10.1227/01.NEU.0000335650.09473.D3. 2020 Apr 11;21(8):2670. doi: 10.3390/ijms21082670. 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